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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Single-cell RNA editing identifies aggressive and favorable cellular states in chronic myelomonocytic leukemia

Nisansala Wickramasinghe1, Doan Bui1, Surendra Neupane2

  • 1Versiti Blood Research Institute, Milwaukee.

Haematologica
|September 3, 2026
PubMed

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RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...