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Updated: Sep 4, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Visualization of Microcirculation Using GOKO Bscan-ZD in a Patient with Chronic Limb-Threatening Ischemia: A Case
Takafumi Fujita1, Makoto Sugihara1, Kaori Mine1
1Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Fukuoka, Japan.
Abstract:
A 50-year-old man with type 2 diabetes mellitus was admitted for chronic limb-threatening ischemia (CLTI). Ulcers involved several toes on both feet. Angiography of the left lower extremity demonstrated severe below-the-ankle arterial disease with markedly compromised pedal runoff. After unsuccessful endovascular therapy of the left lower extremity, low-density lipoprotein (LDL) apheresis was initiated for limited-option CLTI. An increase in microcirculatory flow in the left foot was observed after LDL apheresis, as assessed by angiography and GOKO Bscan-ZD. Complete wound healing was achieved after a transmetatarsal amputation. GOKO Bscan-ZD may represent a novel noninvasive method with which to evaluate microcirculation.

