PIEZO Channels in Metabolism and Metabolic Diseases: Research Advances and Therapeutic Strategies

This review aims to summarize the current knowledge on the role of mechanical-gated ion channel PIEZO in body metabolism and metabolic diseases, as well as the latest evidence of PIEZO1 channels as a therapeutic strategy for metabolic diseases.

PIEZO channels are mechanosensitive ion channels that play a crucial role in converting mechanical stimuli into biological signals. They participate in numerous physiological and pathological processes within the human body. Recently, the importance of PIEZO channels in body metabolism and metabolic diseases has garnered significant attention. This review summarizes the current status of research in carbohydrate and lipid metabolism, energy metabolism, and bone metabolism. It also examines the role and mechanisms of PIEZO channels in obesity, diabetes and its complications, osteoporosis, metabolic syndrome, and other diseases. Furthermore, we organize and discuss the potential for targeting PIEZO channels through multi-faceted therapeutic strategies to treat metabolic diseases. PIEZO channels play a crucial role in the body's metabolism, regulating the body's glucose metabolism, energy metabolism, lipid metabolism, and bone metabolism. Moreover, PIEZO channels are potential therapeutic targets for metabolic diseases, capable of preventing and treating obesity, diabetes and its complications, osteoporosis, metabolic syndrome, and other diseases.