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Hot and Sp(l)icy phosphatase: A potential thermosensor in mammals

Márton Szabó1, Ritwick Sawarkar2

  • 1Department of Biochemistry, University of Cambridge, Cambridge, UK.

Molecular Cell
|September 3, 2026
PubMed

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...