Related Experiment Video
Updated: Sep 5, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Enteric glial serotonin signaling drives anti-tumor immunity in colorectal cancer
1The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Peripheral serotonergic signaling has been implicated in diverse physiological processes, yet its role in coordinating glial-immune interactions remains poorly understood. In this issue of Cell, Wen and colleagues identify enteric glial cells as critical effectors of peripheral 5-HT2AR agonism, uncovering a serotonergic neuroimmune circuit that drives cytotoxic T cell-mediated immunity against colorectal cancer.
Related Concept Videos
Gut-Brain Axis
Amebiasis
