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All you need to know about testosterone results: caution and feedback from laboratories
Nathalie Reix1, François Fraissinet2, Safouane Hamdi3
1Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Strasbourg, France; ICube UMR 7357, University of Strasbourg/CNRS, Federation of Translational Medicine of Strasbourg (FMTS), Strasbourg, France.
Abstract:
This article, presenting three clinical cases, discusses the analytical issues of testosterone measurement in blood (immunoassay and liquid chromatography and mass spectrometry). It also describes the different circulating testosterone fractions (total, free and bioavailable) and how to measure or calculate them. Beyond these analytical aspects, the article addresses the challenges encountered in establishing reference ranges and the specific difficulties related to different patient populations: men, women and children. Finally, in light of the evidence outlined in the article, we review the three cases.
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