Related Experiment Video
Updated: Sep 5, 2026

A Scalable, Cell-Based Method for the Functional Assessment of Ube3a Variants
Published on: October 10, 2022
A comprehensive review on the molecular basis and therapeutic potential of UBE2M in cancer
1Department of Emergency Surgery, Lanzhou University Second Hospital, 730000 Lanzhou, China.
Abstract:
Ubiquitin-conjugating enzyme 2M (UBE2M), a critical E2 conjugating enzyme in the neddylation pathway, has emerged as a pivotal regulator of cancer progression through its involvement in ubiquitination/neddylation cascades, oncogene-tumor suppressor interactions, and cellular homeostasis. This review synthesizes current evidence on UBE2M's molecular roles in cancer, including its function in protein degradation, cell cycle control, and metabolic reprogramming. We further explore its diagnostic utility as a biomarker, and therapeutic potential as a target for small-molecule inhibitors and combination therapies. By integrating findings from preclinical models and clinical datasets, this review establishes UBE2M as a multifaceted node in cancer biology with significant implications for personalized oncology.
More Related Videos
09:47Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
Published on: May 10, 2022
10:25Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
Published on: November 22, 2024
Related Concept Videos
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...