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Updated: Sep 5, 2026

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
Published on: March 22, 2018
Lamin-ating the genome: quantitative gatekeeping of replication initiation
Bibudha Parasar1, Siavash Moghadami2, Longzhi Tan1
1Department of Neurobiology, Stanford University, Stanford, CA, USA.
Abstract:
Discovered in the 1970s, nuclear lamins control chromatin organization and are linked to many diseases. Zhang et al. now find that lamin A/C quantitatively constrains DNA replication initiation by limiting chromatin accessibility and sequestering proliferating cell nuclear antigen, extending lamin's long-known role in replication to the control of origin firing.
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