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Updated: Sep 5, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Published on: April 4, 2012
Closing the recapitulation gap in obesity-conditioned TNBC drug development
Karim I Budhwani1,2, Erica M Stringer-Reasor3, Anna G Sorace3
1CerFlux, Birmingham, AL, USA. IronMan@CerFlux.com.
Abstract:
Preclinical cancer models do not always recapitulate clinical treatment response, as therapeutic response may depend on tissue context the model does not reproduce. Using obesity-conditioned triple-negative breast cancer as a lens, we argue that the tumor microenvironment acts through dual gates-controlling access and altering behavior-and propose the recapitulation gap as a measurable model-to-patient divergence to guide fit-for-purpose drug development.
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