Related Experiment Video
Updated: Sep 6, 2026

07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Posttherapy [18F]FDOPA PET Findings in an Anaplastic Pleomorphic Xanthoastrocytoma With a BRAF V600E Mutation
Jacopo Passoni1, Andrea Rossi2, Claudia Milanaccio3
1Department of Health Sciences (DISSAL), University of Genova.
Clinical Nuclear Medicine
|September 4, 2026
Abstract:
Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare pediatric high-grade glioma (pHGG). We report a 10-year-old boy with a left temporal APXA harboring a BRAF V600E mutation, who presented with generalized tonic-clonic seizures 3-4 times weekly, treated with combined BRAF and MEK inhibition. This case illustrates the utility of [18F]FDOPA PET in monitoring targeted therapy, providing metabolic information that preceded and complemented conventional imaging.
Keywords:
BRAF V600E mutationanaplastic gliomapediatric brain tumorpleomorphic xanthoastrocytomaposttherapy imaging
