Related Experiment Video
Updated: Sep 6, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total Syntheses and Structural Revision of Menominins A and B
Deelip S Rekunge1, Kyungsoo Oh2, Chaeyeon Cho1
1College of Pharmacy, Kangwon National University, Gangwondaehak-gil 1, Chuncheon, Gangwon-do24341, Republic of Korea.
Abstract:
This work reports the stereoselective total synthesis and structural revision of menominins A (1) and B (2) featuring a 3,8-dihydroxy-2-methyltetradecanoic acid residue with a (2R,3R,8S) configuration as a key stereochemical element. This strategy features Evans aldol reactions, Mitsunobu inversion, and ring-closing metathesis as the key steps. Extensive analysis of the spectral data for the synthetic material, combined with reported data, led to structural revisions of menominins A (1) and B (2).
More Related Videos
Related Concept Videos
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Prochirality
Structure of Amines

