Rhodium-Catalyzed Selective Amination of 1-Pyridyl-o-carboranes with N-Boc-O-tosylhydroxylamine: Synthesis of Primary
Wen-Jin Zou1, Xuan-Hao Cao1, Shuo Tang2
1State Key Laboratory of Environment-friendly Energy Materials and School of Materials and Chemistry, Southwest University of Science and Technology, Mianyang, Sichuan621010, P. R. China.
Abstract:
This work discloses a rhodium-catalyzed selective amination of the B-H bond of 1-pyridyl-o-carboranes with N-Boc-O-tosylhydroxylamine (TsONHBoc) via direct B-H activation. A series of primary carboranyl amine derivatives decorated with diverse active groups have been synthesized in moderate yields under mild conditions. This work offers a practical and facile approach for the synthesis of primary carboranyl amines and has important value for application in medicinal chemistry and functional materials.
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