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Updated: Sep 6, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Synthesis of Diarylheptanoids Using Acetone and Alcohols via a Catalytic Borrowing Alkylation Strategy
Abhijit V More1, Bhakti M Bate1, Dashrat Vishambar Sutar1
1Department of Chemistry, Indian Institute of Science Education and Research, Pune411008, India.
Abstract:
A Ru-catalyzed sequential borrowing hydrogen strategy for the synthesis of diarylheptanoid frameworks is reported. The cross-coupling of alcohols with acetone provides alkylated ketones in high yields, followed by selective α-alkylation with diverse alcohols to afford unsymmetrical diarylheptanoid precursors. This approach features a broad substrate scope and good functional group tolerance and is demonstrated through the concise synthesis of several natural diarylheptanoids, including Acerogenin C, Acerogenin G, Engelhardione, Muricarpone, Yakuchinone, and Pterocarine derivatives.
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