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Updated: Sep 6, 2026
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Biomarkers for Detecting and Predicting Macular Neovascularization in Age-Related Macular Degeneration Using Optical
Parva Pourbagherkhah1, Hemn Baghban Jaldian2
1Department of Optometry, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.
Purpose:
This systematic review evaluates the role of optical coherence tomography angiography (OCTA)-based biomarkers in detecting and predicting macular neovascularization (MNV) in age-related macular degeneration (ARMD).
Methods:
A comprehensive literature search was conducted in PubMed, Web of Science, Scopus and Google Scholar up to 20 May 2026, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria encompassed original cohort and cross-sectional studies reporting OCTA-derived quantitative and qualitative biomarkers associated with MNV.
Results:
A total of 203 articles were initially identified, with 11 studies meeting the eligibility criteria, comprising 642 eyes. Key OCTA biomarkers included vascular density, MNV area, total vessel length, and choroidal vascularity index, which demonstrated strong associations with disease activity and progression.
Conclusion:
OCTA-derived biomarkers offer a non-invasive and effective means for detecting and monitoring MNV in ARMD. Despite current challenges in standardization and interpretation, integrating these biomarkers into clinical practice could improve early diagnosis and personalized treatment strategies.
