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A systematic review: management of radiation-induced moist desquamation
Sneha Raja1, Sujatha Kuppusamy1, Christian Gnanaraj Johnson2
1Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Background:
Radiotherapy is a cornerstone in cancer treatment, but is frequently correlated with acute cutaneous toxicity, particularly in patients with head, neck, and breast cancers. This systematic review evaluates the efficacy of interventions for managing grade III moist desquamation among various cancer patients receiving radiotherapy.
Materials And Methods:
A total of 676 studies were screened, and 10 randomised controlled trials were analysed based on inclusion criteria.
Results:
Interventions such as Mepitel Film, boron-based gel, and 0.1% Mometasone Furoate demonstrated significant efficacy in reducing the incidence and severity of moist desquamation compared to standard creams or placebo. Hydroactive colloid gels and aloe vera showed promise in alleviating symptoms and improving treatment adherence. Betamethasone effectively reduced grade 2 dermatitis but limitedly impacted severe grade 3 reactions.
Conclusions:
The findings highlight the importance of tailoring interventions to individual patient needs and emphasize the need for further studies to validate treatments, explore long-term outcomes, and improve patient quality of life during radiotherapy.
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