Resting-state Functional Connectivity in Default Mode and Frontoparietal Networks Predicts Directed Forgetting

Directed forgetting (DF) refers to the goal-directed modulation of memory, typically manifested as superior memory for information cued to be remembered (TBR) compared to information cued to be forgotten (TBF). Although prior studies have emphasized task-evoked neural mechanisms of DF, it remains unclear whether intrinsic brain network organization contributes to individual differences in memory control. The present study examined whether resting-state functional connectivity within and between the default mode network (DMN) and frontoparietal network (FPN) predicts individual differences in DF performance. Forty-seven healthy college students (31 females; aged 18-28 years) underwent resting-state fMRI scanning and completed an item-method DF task. Behavioral results showed significantly better recognition for TBR than TBF items, confirming a DF effect. Connectivity analyses revealed that, 1) stronger within-DMN connectivity centered on the right precuneus/posterior cingulate cortex (pCun/PCC) was associated with better memory for TBR items and a larger DF effect. 2) Stronger within-FPN connectivity, especially between the right dorsolateral prefrontal cortex and bilateral inferior parietal lobule, predicted poorer memory for TBF items. 3) Moreover, stronger anticorrelation between the FPN and mnemonic regions was associated with better memory for TBR items, poorer memory for TBF items, and a larger DF effect. These findings suggest that DF depends on dissociable but coordinated intrinsic network properties supporting selective remembering, active forgetting, and functional segregation between mnemonic and control systems.