Associations of vitamin D, hepatic function and inflammatory biomarkers with obesity: A cross-sectional analysis

Obesity is associated with hepatic dysfunction, chronic inflammation and vitamin D deficiency, but their interrelationship remains incompletely understood. Therefore, it is of interest to compare the liver function, inflammatory and vitamin D-PTH biomarkers between 100 obese adults (BMI ≥30 kg/m²) and 100 age-matched non-obese controls. Obese participants showed significantly higher ALT, AST, ALP, GGT, CRP, IL-6, fibrinogen and PTH levels, with lower serum 25(OH)D concentrations. Regression analysis identified CRP (OR=1.38, 95% CI: 1.24-1.54) and GGT (OR=1.35, 95% CI: 1.20-1.52) as the strongest positive predictors, while 25(OH)D showed a significant inverse association with obesity (OR=0.79, 95% CI: 0.68-0.91). Thus, data shows the combined contribution of hepatic dysfunction, systemic inflammation and vitamin D imbalance to obesity-related metabolic disturbances and support their early clinical assessment.