Bavachin inhibits cell viability and migration in human pancreatic cancer cells

Pancreatic cancer is an aggressive malignancy with poor survival and limited treatment options, highlighting the need for novel therapies. Bavachin, a naturally occurring compound derived from Psoralea corylifolia , has demonstrated anticancer activity in other cancer models. We evaluated the effects of bavachin on PANC-1 pancreatic cancer cells in vitro . Sulforhodamine B and trypan blue assays assessed cell viability and determined the IC₅₀, while a wound healing assay evaluated migration. Bavachin significantly reduced PANC-1 cell viability (IC₅₀ = 30.30 μM) and inhibited migration, providing evidence that bavachin affects viability and ability to migrate in PANC-1 cells.