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peakScout - a biologist-friendly tool for bidirectional peak-gene mapping
Alexander L Lin1, Lana A Cartailler1, Jean-Philippe Cartailler1
1Creative Data Solutions, Center for Stem Cell Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville TN 37027.
Motivation:
Translating genomic peak data into biologically meaningful knowledge typically requires bioinformatics expertise, creating a barrier for non-technical users. We developed peakScout to bridge the gap between peaks, genes and gene annotations, enabling users to quickly focus on biological context and not bioinformatics skills, in a reproducible and robust fashion.
Results:
peakScout is a command line and web-based program that performs bidirectional mapping between genomic peaks and genes. The peak-to-gene mode identifies which genes are potentially regulated by specific genomic regions, while the gene-to-peak mode reveals which regulatory elements might influence particular genes of interest. An algorithm for nearest-feature detection handles the complex spatial relationships between genomic elements, considering factors like distance constraints and feature overlaps.
Availability:
The web version of peakScout is available at https://vandydata.github.io/peakScout/. The command line version is available at https://github.com/vandydata/peakScout and archived on Zenodo (https://doi.org/10.5281/zenodo.21211605) under the GNU Affero General Public License v3.0. Installation instructions, example datasets, and usage examples are provided in the GitHub repository README file.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
