Three Adult Cases of ADHD With Comorbid Tic Symptoms Successfully Treated With Guanfacine Monotherapy

Tic disorders typically begin in childhood and often improve by adulthood, but some individuals continue to experience tic symptoms into adult life. Tic disorders frequently co-occur with Attention-deficit/hyperactivity disorder (ADHD), and in such cases α2-adrenergic agonists are recommended as a treatment as they can address both conditions. However, evidence in adults with ADHD and comorbid tic disorders is limited, as most studies have focused on pediatric populations. Here, we present three adult male patients with childhood-onset ADHD and chronic tic symptoms who showed a rapid and significant improvement in tics with low-dose extended-release guanfacine (GXR) monotherapy. These cases suggest that GXR can effectively treat both ADHD and tic symptoms in adults-a finding that has not been well documented in prior adult studies.