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Updated: Sep 9, 2026

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
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[Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer 
Brain Metastasis: Mechanisms and

Heqi Yang1, Qinghua Zhou1

  • 1Lung Cancer Institute/Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|September 7, 2026
PubMed

Keywords:
Brain metastasisLung neoplasmsSingle-cell sequencingSpatial omicsTumor microenvironment

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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...