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Published on: May 31, 2018
[Alcohol liver disease: immunoregulatory mechanisms and precision therapeutic targets]
1Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, China Key Laboratory of Anti-inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Hefei 230032, China Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei 230032, China.
Abstract:
Alcohol liver disease (ALD) represents a major health challenge worldwide, with particularly high mortality in severe alcohol-associated hepatitis. Inflammation plays a central role in ALD progression, and immune cells along with their inflammatory mediators contribute to disease development through actions in both the liver and extrahepatic organs. Currently, there is a lack of targeted therapies that can effectively block chronic ALD progression or intervene in alcohol-related acute liver failure. This article elucidates the core mechanisms by which immune heterogeneity drives the development and progression of ALD and influences treatment responses, summarizes current clinical research progress in anti-inflammatory therapies, and highlights promising future directions, particularly biomarker-guided precision therapy.
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