Related Experiment Video
Updated: Sep 9, 2026
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
Published on: July 11, 2025
Association Between Isolated Maternal Hypothyroxinemia and Adverse Maternal and Infant Outcomes
Wenlei Zhang1, Shixuan Liu2, Jianlan Zheng3
1Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, China.
Aim:
The current meta-analysis aims to assess the incidence of isolated maternal hypothyroxinemia (IMH) and its impact on pregnancy complications and adverse pregnancy outcomes.
Methods:
PubMed, Embase, Web of Science, and Cochrane databases were searched until November 15, 2024. Cochrane, a risk-of-bias assessment tool, was used to evaluate the quality of literature; R Studio and Stata 15.0 were employed for data analysis and publication bias assessment.
Results:
In total, 22 cohort studies were analyzed, with a sample size of 33,1640 cases, including 16 390 IMH patients. The meta-analysis revealed that the prevalence of IMH was 5.7% (95% CI: 3.5, 8.4%). Compared to pregnant women with normal thyroid function, the prevalence of gestational diabetes mellitus (GDM) in IMH patients was 1.12% (95% CI: 1.01,1.24), macrosomia was 1.41% (95% CI: 1.12, 1.65), preterm birth was 1.26% (95% CI: 1.12, 1.41), and preeclampsia/eclampsia was 1.26% (95% CI: 1.12, 1.41) (p < 0.05).
Conclusions:
Patients with IMH have an elevated risk of GDM, preeclampsia, eclampsia, preterm birth, and macrosomia relative to normal pregnant women. It is anticipated that future studies will further confirm the complications related to pregnancy in patients with IMH.
More Related Videos
03:19Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Related Concept Videos
01:07Teratogenicity
01:27Hyperthyroidism II: Pathophysiology
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
02:57Meiosis vs. Mitosis
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
01:22Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...