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Acute menopausal transition associated with clomiphene therapy: Two case reports
British Journal of Obstetrics and Gynaecology
|March 1, 1979
Summary
Clomiphene citrate treatment for infertility unexpectedly induced a rapid, premature menopause in two women. This menopausal transition persisted for at least three years post-treatment.
Area of Science:
- Reproductive Endocrinology
- Gynecology
- Pharmacology
Background:
- Anovulation and secondary infertility are common reproductive challenges.
- Clomiphene citrate is a widely used medication to induce ovulation.
- Understanding treatment side effects is crucial for patient safety.
Observation:
- Two patients with anovulation and secondary infertility received clomiphene citrate therapy.
- Intermittent blood samples were collected during the initial three months of treatment.
- One patient did not ovulate or menstruate; the other experienced limited bleeding.
Findings:
- Both patients exhibited a rapid and premature menopausal transition.
- This induced menopausal state persisted for over three years.
- Hormonal analyses confirmed the menopausal status.
Implications:
- Clomiphene citrate may have unforeseen and prolonged adverse effects on ovarian function.
- This case highlights the potential for drug-induced premature menopause.
- Further research is needed to elucidate the mechanisms and identify at-risk individuals.