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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Age-dependent immune landscapes affect influenza vaccine effectiveness and guide precision strategies
Jing Liu1, Zhegang Zhang1, Jiayou Zhang1
1Wuhan Institute of Biological Products Co., Ltd., Wuhan, China.
Abstract:
Influenza vaccine effectiveness exhibits significant heterogeneity across age groups, largely shaped by lifelong immune remodeling. This review adopts a continuous spectrum perspective-spanning immune development, immune maturation, and immunosenescence-to delineate host immune responses to influenza across different life stages. Subsequently, the influence of these age-dependent differences on vaccine effectiveness is discussed. Based on these insights, an age-specific vaccine development strategy is proposed to guide differentiated vaccine optimization approaches for children, adults, and the elderly. This review provides a theoretical basis for transitioning from a "one-dose-fits-all" vaccination model and toward an age-specific precision paradigm.
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