Management of Rhabdomyolysis Complicated by Acute Kidney Injury Using Fluid Therapy and Mannitol: A Case Report

Rhabdomyolysis is a potentially life-threatening condition that may be complicated by acute kidney injury (AKI), requiring prompt recognition and early treatment to prevent adverse outcomes. We report the case of a young female patient who developed rhabdomyolysis complicated by AKI. Initial laboratory evaluation demonstrated a peak creatine kinase (CK) level of 3,976 U/L, together with biochemical evidence of AKI. The patient was managed with aggressive intravenous crystalloid therapy, close monitoring of urine output and renal function, and adjunctive low-dose mannitol after individualized clinical assessment. During hospitalization, she showed progressive clinical improvement, recovery of urine output, normalization of renal function, and a marked decline in CK levels without requiring renal replacement therapy. She was discharged in stable condition with complete clinical recovery. This case highlights the importance of early recognition, prompt fluid resuscitation, and individualized management of rhabdomyolysis complicated by AKI while emphasizing that the favorable outcome observed in this patient does not establish a causal benefit of adjunctive mannitol.