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Updated: Sep 10, 2026

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice
Published on: September 29, 2023
Anterior Cruciate Ligament Injury: Beyond the Ligament- A Neurophysiological Perspective
Hedaya Nihad Rizeq1, Tyler Whittier1
1Department of Food Systems, Nutrition, and Kinesiology, Montana State University, Bozeman, MT.
Abstract:
The anterior cruciate ligament (ACL) is not merely a passive stabilizer of the knee, yet its injuries are still commonly treated as a mechanical problem despite growing evidence implicating the central nervous system (CNS). This mini review highlights the ACL as a critical sensory organ, housing mechanoreceptors that provide afferent feedback regarding the knee position. We further examine evidence across peripheral, cortical, and supraspinal levels to characterize CNS involvement in ACL injury.
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