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Lending an ear to the lung
1Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Abstract:
The unprecedented recent advancement in the field of interoception (sensing self) has introduced neuromodulation as a realistic treatment approach. Shibuya et al. identified an ear-to-lung reflex in which activation of auricular-innervating TRPV1+ vagal sensory neurons functions through neuropeptide CGRPβ to suppress allergic airway inflammation, providing an elegant example of exteroceptive control of interoception and a mechanism for transcutaneous neuromodulation.
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