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Updated: Sep 10, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Bismuth(III)-catalyzed three-component selenation of imidazo[1,2-a]pyridines or related arenes with selenium and
Naoki Aiba1, Mio Matsumura1, Yuki Tada1
1School of Pharmaceutical Sciences, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
Abstract:
Unsymmetrical diaryl selenides bearing heteroaromatic moieties have attracted increasing attention because of their notable biological activities. In this paper, a novel bismuth-catalyzed three-component reaction is reported for the synthesis of 3-selanylimidazopyridines from imidazopyridines, arylboronic acids, and elemental selenium. The reaction proceeded under aerobic conditions at 100 °C using BiI3 (10 mol %) as the catalyst, affording the desired products in moderate to good yields. The application of this method to other electron-rich arenes was also explored. This transformation represents the first example of a three-component reaction catalyzed by a bismuth reagent. The use of BiI3, a non-hygroscopic and low-toxicity catalyst, offers an alternative to traditional transition-metal-catalyzed systems.
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