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![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-catalyzed synthesis of multifunctionalized 1,2-dihydropyridines using solid calcium carbide as an alternative
Wei Chen1, Jinhui Yang2, Zheng Li1
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, P. R. China. lizheng@nwnu.edu.cn.
Abstract:
A variety of multifunctionalized 1,2-dihydropyridines are efficiently constructed through copper(I)-catalyzed one-pot three-component reactions using readily available 2-[(amino)methylene]malononitriles and sulfonyl azides, as well as inexpensive and easy-to-handle solid calcium carbide instead of flammable and explosive gaseous acetylene. This concise protocol enables the direct formation of important 1,2-dihydropyridines bearing amino, cyano, and sulfonylimino groups in one step by installing two C-N bonds and one C-C bond. This strategy has salient features of broad substrate scope, a low-cost catalyst, mild reaction conditions, high efficiency, simple workup procedures, and gram-scale applicability.
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