Related Experiment Video
Updated: Sep 12, 2026

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
Published on: April 10, 2018
Sharing is not caring: Near-germline and polyreactive memory B cells in primary dengue
Kelsey E Lowman1, Rosemary A Aogo1, Leah C Katzelnick1
1Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Abstract:
Verdonckt et al.1 characterize B cell receptor repertoires after dengue virus 1 challenge and observe atypical primary responses enriched for polyreactive and public, near-germline memory B cell sequences containing dengue-associated motifs that could represent an inherent constraint of dengue immunobiology.
Related Concept Videos
Cross-reactivity
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cells of the Adaptive Immune Response
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Humoral Immune Responses
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

