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From heart to BAT: Rethinking mouse models of human BAT
1Research Unit Adipocytes & Metabolism, Helmholtz Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Cell Reports
|September 9, 2026
Abstract:
Ran et al. identify a heart-associated origin of mouse supraclavicular brown adipose tissue (BAT). Their findings challenge the dominance of interscapular BAT in mouse research and suggest that anatomically corresponding depots may better inform translation to human thermogenic fat.