Related Experiment Video
Updated: Sep 12, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Exploring the Anticancer Potential of Schiff Base Complexes: A Mini-Review
Atif Ahmad1, Anam1, Marcos V Palmeira-Mello2
1Departamento de Química Analítica, Físico-Química e Inorgânica, Instituto de Química, UNESP - Universidade Estadual Paulista, Araraquara, Brazil.
Abstract:
Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes. These metal-based compounds have attracted significant attention due to their enhanced biological activities, particularly their ability to act toward anticancer chemotherapy. This mini-review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations. Cytotoxicity and interactions with biological targets have been detailed. The mechanisms underlying the capacity of these complexes to induce cell death in cancer cells are also described.
Related Concept Videos
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
