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Nodal/Smad2 signaling maintains diapause in the mouse embryo
1Centre de recherche en reproduction et fertilité, Université de Montréal, 3200 rue Sicotte, St-Hyacinthe J2S 2M2, QC, Canada.
Developmental Cell
|September 9, 2026
Abstract:
Embryonic diapause is a reversible dormant state that allows mammalian blastocysts to survive periods of environmental or metabolic stress. In this issue of Developmental Cell, Furlan et al.1 report that Nodal/Smad2 signaling sustains diapause by repressing Pparg-driven lipid storage in the blastocyst.