Related Experiment Video
Updated: Sep 12, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
An upside of obesity: Diet-microbe synergy aids immunotherapy
Laura A Bolte1, Johannes R Björk2, Thomas Vogl3
1Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands; Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Abstract:
While obesity is generally associated with unfavorable health outcomes, there are notable exceptions. In cancer immunotherapy, epidemiological studies consistently link obesity to improved checkpoint inhibitor responses. Desharnais et al. show in mouse models that this paradox is driven by diet-dependent interactions with the gut microbiome, not obesity itself.
Related Concept Videos
Dysbiosis of the Gut Microbiota
Tumor Immunotherapy
Psychoneuroimmunology: Diabetes and Cancer
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Microorganisms in Medicine and Therapeutics
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
