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Updated: Sep 11, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Eating to heal: dietary interventions as emerging immune-based therapeutic strategies
Wenyu Cui1, Zhangying Wang1, Xiangyuan Li2
1Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, PR China.
Abstract:
Clinical immunology is increasingly recognizing diet not merely as baseline metabolic sustenance but as a tunable pharmacological tool. By targeting conserved nutrient-sensing networks and the microbiome, defined nutritional protocols-such as fasting mimetics and specific macronutrient titrations-can actively rewire immune responses. In this review, we examine how manipulating macronutrient stoichiometry, systemic energy availability, and chrononutrition can be strategically deployed to enhance antitumor immune efficacy, promote tissue regeneration, and drive the resolution of chronic inflammation. Finally, we dissect the translational bottlenecks that must be overcome to elevate dietary strategies from broad lifestyle guidelines to prescribable precision immunotherapies.
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