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Updated: Sep 11, 2026

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
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The integrated Lei-CNS PBPK-PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in

Mengxu Zhang1, Thomas I F H Cremers2,3, Vivi Rottschäfer4,5

  • 1Division of Systems Pharmacology and Pharmacy, Predictive Pharmacology Group, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands.

British Journal of Clinical Pharmacology
|September 10, 2026
PubMed
Abstract

Keywords:
BBBCNSPBPK modelactive influxbrain extracellular fluidclozapineneutral lipids

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