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Published on: September 12, 2016
Early switching to ofatumumab avoids a rebound effect after natalizumab cessation in multiple sclerosis patients
Jérôme De Seze1, Emmanuel Bernard2, Colyne Betsch3
1Neurological Department, Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Background:
A risk of disease reactivation has been clearly identified after natalizumab cessation in patients with multiple sclerosis (MS). Several studies have demonstrated a low risk of reactivation or rebound in patients switching to anti-CD20, but limited data are available concerning ofatumumab.
Objective:
In the present study, we evaluated a cohort of 61 MS patients who switched from natalizumab to ofatumumab.
Results:
After a mean follow-up of 2.4 years (range: 6 months to 4 years), none of the patients had experienced any clinical relapse or magnetic resonance imaging reactivation.
Conclusion:
We confirm that ofatumumab is likely an effective option, using a short washout period following natalizumab discontinuation.
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