Related Experiment Video
Updated: Sep 11, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
Clinical Consequences of Inadvertent Intramuscular Administration of Subcutaneous Risperidone Formulation
Emma Ashley1, Arnela Aalomerovic1, Kyle Blackmer1
1Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA, louisville.edu.
Abstract:
Long-acting injectable (LAI) antipsychotics have been predominately administered intramuscularly (IM). Recently, subcutaneous (SC) formulations have been developed. Information regarding what occurs when the drug is not administered properly is lacking. A 23-year-old woman with bipolar disorder, currently manic with psychosis, was responding well to a combination of lithium and risperidone. She accepted a LAI of SC risperidone, but the drug was administered IM by error. The improvement she had already displayed was partially lost, and oral risperidone had to be reinitiated. She complained of mild pain at the injection site, but no other adverse consequences were noted. When a SC formulation is administered IM, it results in mild muscle pain, and unpredictable release of risperidone, but no other notable clinical problems.
Related Concept Videos
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Pharmaceutical Poisoning: Potential Scenarios
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Parenteral Anesthetics: Overview

