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Updated: Sep 12, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Comparison of Structure-Function Relationships between Tablet-Based Perimetry and Conventional Bowl Perimetry: A
Jan Niklas Lüke1, Amelie Poell1, Philip Enders1
1Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Objective:
To investigate the structure-function relationship between OCT parameters of the optic nerve head (ONH) and corresponding sectoral mean sensitivity (MS) values obtained using tablet-based perimetry (TP) and conventional bowl perimetry (CBP).
Design:
Post hoc analysis of a cross-sectional observational study.
Subjects:
A total of 140 eyes from 77 patients with suspected or confirmed glaucoma were included after exclusion.
Methods:
Participants underwent visual field testing using TP and conventional bowl-based perimetry (Octopus 900; G-Pattern), as well as spectral-domain OCT (SD-OCT; Spectralis) of the ONH, within an 8-week interval. Based on the Garway-Heath map, visual field sensitivity points were assigned to corresponding sectors of the peripapillary retinal nerve fiber layer (pRNFL) and Bruch membrane opening (BMO)-minimum rim width (MRW). Mean sensitivity values were converted to a linear scale. Structure-function relationships were assessed using Spearman's rank correlation coefficient.
Main Outcome Measures:
Sectoral and global correlations between visual field MS and OCT-derived BMO-MRW and pRNFL thickness, comparing TP with conventional bowl-based perimetry.
Results:
Both BMO-MRW and pRNFL thickness demonstrated statistically significant moderate-to-strong correlations with visual field sensitivity across most sectors and at the global level (BMO-MRW: ρ = 0.64; pRNFL: ρ = 0.69; both P < 0.01). Global structure-function correlations were comparable between TP and CBP (BMO-MRW: ρ = 0.65 vs. 0.64; P = 0.87). In glaucoma-relevant temporo-inferior sectors, TP showed equal or stronger correlations with structural parameters than CBP, whereas weaker associations were observed in nasal sectors.
Conclusions:
Tablet-based perimetry demonstrates a reliable structure-function relationship with ONH morphometry, with correlations comparable to those obtained using conventional bowl-based perimetry. These findings support the potential clinical utility of TP for structural-functional assessment in glaucoma.
Financial Disclosure(S):
The authors have no proprietary or commercial interest in any materials discussed in this article.
