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Updated: Sep 12, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Comparison of Structure-Function Relationships between Tablet-Based Perimetry and Conventional Bowl Perimetry: a
Jan Niklas Lüke1, Amelie Poell1, Philip Enders1
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Ophthalmology, Cologne, Germany.
Objective:
To investigate the structure-function relationship between optical coherence tomography (OCT) parameters of the optic nerve head and corresponding sectoral mean sensitivity (MS) values obtained using tablet-based perimetry (TP) and conventional bowl-based static perimetry (CBP).
Design:
Post-hoc analysis of a cross-sectional observational study.
Subjects:
A total of 140 eyes from 77 patients with suspected or confirmed glaucoma were included after exclusion.
Methods:
Participants underwent visual field testing using tablet-based perimetry and conventional bowl-based perimetry (Octopus 900; G-Pattern), as well as spectral-domain optical coherence tomography (SD-OCT, Spectralis) of the optic nerve head, within an eight-week interval. Based on the Garway-Heath map, visual field sensitivity points were assigned to corresponding sectors of the peripapillary retinal nerve fiber layer (pRNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW). Mean sensitivity values were converted to a linear scale. Structure-function relationships were assessed using Spearman's rank correlation coefficient.
Main Outcome Measures:
Sectoral and global correlations between visual field mean sensitivity and OCT-derived BMO-MRW and pRNFL thickness, comparing tablet-based perimetry with conventional bowl-based perimetry.
Results:
Both BMO-MRW and pRNFL thickness demonstrated statistically significant moderate to strong correlations with visual field sensitivity across most sectors and at the global level (BMO-MRW: ρ = 0.64; pRNFL: ρ = 0.69; both P < 0.01). Global structure-function correlations were comparable between TP and CBP (BMO-MRW: ρ = 0.65 vs. 0.64; P = 0.87). In glaucoma-relevant temporo-inferior sectors, TP showed equal or stronger correlations with structural parameters compared with CBP, whereas weaker associations were observed in nasal sectors.
Conclusions:
Tablet-based perimetry demonstrates a reliable structure-function relationship with optic nerve head morphometry, with correlations comparable to those obtained using conventional bowl-based perimetry. These findings support the potential clinical utility of tablet-based perimetry for structural-functional assessment in glaucoma.
