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Updated: Sep 12, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
[Survey of Actual Aspirin Use and Deep Vein Thrombosis in Patients with Pomalidomide-Containing Therapy Using a
Yoji Kawase1, Yuri Kawase, Hisaki Asano
1Dept. of Pharmacy, Ichinomiya Municipal Hospital.
Abstract:
Pomalidomide (POM) is an immunomodulatory drug used to treat multiple myeloma, and low-dose aspirin (ASA) is recommended as a preventive measure against its side effect, deep vein thrombosis (DVT). In this study, we utilized a medical information database to clarify the actual use of ASA in patients receiving POM-containing therapy and to investigate the factors affecting ASA use and its association with DVT prevalence. The ASA usage rate in patients receiving POM-containing therapy from September 2023 to September 2024 was 70.6% (497 of 704 patients). Additionally, the use of bortezomib (BOR) affected the ASA usage rate in patients receiving POM-containing therapy; patients using BOR had a significantly lower ASA usage rate compared to non-users. Meanwhile, the use of BOR also affected the DVT prevalence in patients receiving POM-containing therapy, indicating that BOR use may reduce the risk of DVT development associated with POM.
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