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Energy-barrier models for membrane transport.

L F Del Castillo, E A Mason, L A Viehland

Biophysical Chemistry

|January 1, 1979

Summary

Simple energy-barrier models are surprisingly accurate and broadly applicable, often outperforming irreversible thermodynamics equations. Their main limitations involve high electric fields and multicomponent mixtures.

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Area of Science:

Physical Chemistry
Membrane Science
Thermodynamics

Background:

Energy-barrier models are frequently used to describe transport phenomena in membranes.
Understanding the assumptions and limitations of these models is crucial for accurate predictions.
Comparison with continuum membrane models provides a benchmark for evaluating model performance.

Purpose of the Study:

To identify implicit assumptions within energy-barrier models.
To determine the operational range of validity for these models.
To compare the predictive power of energy-barrier models against irreversible thermodynamics.

Main Methods:

Comparative analysis of energy-barrier models against integrated continuum membrane models.
Evaluation of model accuracy under varying conditions, including deviations from strict validity criteria.
Assessment of model performance in different physical scenarios, such as high electric fields and multicomponent flow.

Main Results:

Simple energy-barrier models demonstrate a wide range of validity and high accuracy, even when conditions are not perfectly met.
Energy-barrier models generally outperform analogous equations from irreversible thermodynamics.
Limitations include potential nonphysical divergences at high electric fields due to transition-state approximation breakdown and challenges in modeling multicomponent mixtures.

Conclusions:

Energy-barrier models are robust and accurate for many applications.
Irreversible thermodynamics equations are often less suitable than energy-barrier models.
Further development is needed to address limitations in high-field regimes and multicomponent systems.

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