Related Experiment Video
Updated: Sep 13, 2026

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
Published on: March 15, 2024
[Extracorporeal blood purification for acute pancreatitis]
T I Shalaeva1,2, G V Rodoman1,2, Yu Yu Golubeva1,2
1Pirogov Russian National Research Medical University, Moscow, Russia.
Objective:
To assess the feasibility of extracorporeal blood purification (EBP) for acute pancreatitis.
Material And Methods:
A retrospective study enrolled 128 patients with moderate-to-severe pancreatitis in 2020-2024. Of these, 53 ones underwent EBP. Clinical outcomes and laboratory parameters were assessed.
Results:
Early effect of EBP was short-term, and long-term dynamics of laboratory parameters did not demonstrate the advantages of this method. The negative effects of extracorporeal treatment included adverse effects on hemostasis system, serum albumin and hemoglobin. With the same baseline severity of organ dysfunction, EBP showed more severe progression and delayed regression of symptoms. Severe dysfunction (SOFA score > 5) was more common by 10%. After 5-6 days, SOFA score was 1.67±0.31 vs. 0.70±0.10 (95% CI 0.45-1.48, P<0.001). Maximum severity of multiple organ failure was higher by 0.75±0.32 points in case of EBP (95% CI 0.12-1.39, P<0.028).
Conclusion:
Routine EBP for extrarenal indications is not advisable in moderate-to-severe acute pancreatitis.
Related Concept Videos
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology
Acute Kidney Injury V: Interprofessional Care
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

