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Updated: Sep 13, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Efficient Synthesis of Cyclopropylamine Derivatives via Deoxygenative Cyclopropanation of Aliphatic Aldehydes with
Yan Wang1, Ying Xu1, Dong Xing1
1Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Molecular Sciences, Anhui Normal University, Wuhu241002, P. R. China.
Abstract:
Herein, we report a multicomponent reaction of aliphatic aldehydes, acyl-stabilized sulfur ylides, and hydrazones that provides streamlined access to cyclopropylamine derivatives. The reaction displays excellent stereoselectivity, a broad substrate scope, good functional group tolerance, and needs mild reaction conditions. In addition, the cyclopropylamine products can be smoothly converted into a diverse range of functionalized 1,4-dihydropyridazines through a possible Cs2CO3-promoted ring-opening/intramolecular cyclization/1,2-hydride-shift cascade.
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