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Updated: Sep 13, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed N-Fluoroallylation of Sulfoximines and Benzophenone Imine with gem-Difluorinated Cyclopropanes
Ebrahim-Alkhalil M A Ahmed1, Wen-Gen Cao1, Shang-Hai Yu2
1College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou325035, China.
Abstract:
Sulfoximines are indispensable core scaffolds in medicinal chemistry and organic synthesis. N-Allylation represents a powerful strategy for enriching the structural diversity of sulfoximines, while fluorine incorporation can effectively enhance the lipophilicity and metabolic stability of functional molecules. Herein, we disclose an efficient Pd-catalyzed N-fluoroallylation of sulfoximines using gem-difluorinated cyclopropylamines. This transformation is enabled by sequential C-C bond activation and C-F bond cleavage, affording a series of N-fluoroallylic sulfoximines bearing monofluoroalkene motifs with excellent Z-stereoselectivity. This protocol features mild reaction conditions and broad substrate compatibility, providing a novel and practical platform for the construction of fluorinated sulfoximine derivatives.
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