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Updated: Sep 13, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Proton-Coupled Electron Transfer-Driven Fragmentation and Functionalization Strategies for Carbohydrate
Kumar Bhaskar Pal1, Jakob Öberg1, Yeersen Patehebieke1
1Department of Chemistry and Molecular Biology, University of Gothenburg, SE 41390Gothenburg, Sweden.
Abstract:
We present a proton-coupled electron transfer (PCET)-mediated strategy for the direct activation of glycosyl alcohols, providing a unified platform for three key transformations: fragmentative hydrogenation, radical conjugate addition, and dual nickel/photoredox-catalyzed cross-coupling. This approach enables efficient access to C(sp3)-H, C(sp3)-C(sp3), and C(sp3)-C(sp2) bonds from conveniently accessible monohydroxy glycosyl donors. The broad substrate scope and functional group tolerance underscore its versatility, offering streamlined routes to structurally complex and pharmaceutically important C-glycosides while expanding the synthetic repertoire of modern carbohydrate chemistry.
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