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Updated: Sep 13, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Palladium-Catalyzed Self- and Cross-Dimerization Annulation of β-CF3-1,3-Enynamides: An Access to Functionalized
Jintong Li1,2, Tianyu Chen1, Huiwen Zhang1
1School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai200241, P. R. China.
Abstract:
An efficient and general method for the synthesis of highly functionalized bicyclo[4.2.0]trienes via a palladium-catalyzed self-dimerization annulation of β-CF3-1,3-enynamides and cross-dimerization annulation of β-CF3-1,3-enynamides with 1,3-enynes was developed. β-CF3-1,3-enynamides bearing a Ts group were identified as optimal reagents for cross-dimerization of two different enynes. In all cases, the reactions proceeded in a regiospecific manner, affording highly functionalized bicyclo[4.2.0]trienes which are challenging to prepare via conventional approaches. Further synthetic transformations of the bicyclo[4.2.0]trienes were explored, highlighting their distinctive reactivity profile and outlining their application in diverse syntheses.
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