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High-resolution flow-zonal centrifuge system.

W J McAleer, W Hurni, E Wasmuth

    Biotechnology and Bioengineering
    |February 1, 1979
    PubMed
    Summary
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    A new Beckman flow centrifuge rotor offers enhanced virus purification. This modified rotor effectively isolates influenza B and herpes simplex viruses with high efficiency.

    Area of Science:

    • Biotechnology
    • Virology
    • Biophysical Chemistry

    Background:

    • Centrifugation is crucial for biological sample purification.
    • Existing rotors may have limitations in achieving high gravitational force and long path lengths for efficient separation.
    • Purification of viruses like influenza B and herpes simplex virus requires advanced techniques.

    Purpose of the Study:

    • To develop and evaluate a modified CF-32 Beckman flow centrifuge rotor.
    • To assess the rotor's performance in terms of sedimentation path length and gravitational force.
    • To determine the rotor's efficacy in purifying human influenza B and herpes simplex viruses.

    Main Methods:

    • Modification of a standard CF-32 Beckman flow centrifuge rotor.
    • Application of the modified rotor for virus purification.

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  • Evaluation of separative capability and extraction efficiency.

    • Main Results:

    • The modified rotor provides a long sedimentation path length.
    • High gravitational force is achieved at the gradient sample interface.
    • Excellent separative capability and extraction efficiency were observed for human influenza B and herpes simplex viruses.

    Conclusions:

    • The modified CF-32 Beckman flow centrifuge rotor is a valuable tool for virus purification.
    • This rotor design offers improved performance for isolating specific viral agents.
    • The technology holds promise for enhanced virological research and diagnostics.