Related Experiment Video
Updated: Sep 13, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
The Overlapping Symptoms of Perimenopause and Opioid Withdrawal: When Hormone Therapy is "Even more Important for My
Abstract:
Hot flushes, or vasomotor symptoms in menopause, are prevalent in both menopause and opioid withdrawal. While our understanding is limited, the physiology and mechanisms behind vasomotor symptoms in menopause and opioid withdrawal hot flushes are likely similar. Both types of hot flushes are associated with an increase in norepinephrine production and dysregulation of β-endorphin levels. In this case, we present the case of a 46-year-old perimenopausal female who misattributed menopausal hot flushes to opioid withdrawal. She initiated methadone; however, her symptoms of hot flushes did not improve. After being referred to a gynecologist, she started hormone therapy, which completely resolved her symptoms. We discuss the potential implications for clinical care given the overlapping physiologic pathways that lead to symptoms of menopause and opioid withdrawal.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Analgesics: Morphine and Other Natural Cogeners
Analgesia and Pain Management
Menopause
Opioid Receptors: Overview
Toxidromes: Clinical Features
