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Updated: Sep 13, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Biopsy-proven dengue virus-associated IgA nephropathy and interstitial nephritis with viral RNA detected in kidney
1Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health, Ministry of Education, Beijing, China; Beijing Key Laboratory of Precision Medicine and New Drug/Equipment Development for Severe Kidney Disease, Beijing, China.
Background:
Dengue virus infection can cause kidney involvement, but biopsy-confirmed cases with both glomerular and tubulointerstitial lesions and molecular evidence of viral presence are rare.
Case Presentation:
A previously healthy 34-year-old man developed fever and dark urine after returning from Vietnam. He presented with acute kidney injury, nephrotic-range proteinuria, hematuria, and elevated aminotransferases. Kidney biopsy revealed IgA nephropathy (Oxford M1E0S0T0C0) with acute interstitial nephritis and granulomatous inflammation. Dengue virus serotype 2 RNA was detected in blood and renal tissue by tNGS. With supportive treatment, renal function, proteinuria, and hematuria completely resolved within one month.
Conclusion:
Dengue infection may trigger concurrent glomerular and tubulointerstitial immune-mediated kidney injury. Molecular detection of viral RNA in renal tissue provides evidence of renal involvement.
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